Mohammad Reza Jafari Nakhjavani; Amir Ghorbanihaghjo; Ozra Dabagh Asadollahipour; Sima Abedi Azar; Tala Pourlak; Aida Malek Mahdavi
Volume 21, Issue 5 , 2019, Pages 1-7
Abstract
Background: The role of vitamin D and cartilage oligomeric matrix protein (COMP) in knee osteoarthritis (OA) still remains con- troversial.Objectives: This study aimed to evaluate serum COMP and 25-hydroxy vitamin D concentrations in patients with knee OA in com- parison to healthy individuals and to ...
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Background: The role of vitamin D and cartilage oligomeric matrix protein (COMP) in knee osteoarthritis (OA) still remains con- troversial.Objectives: This study aimed to evaluate serum COMP and 25-hydroxy vitamin D concentrations in patients with knee OA in com- parison to healthy individuals and to find whether there is a relationship between serum COMP, 25-hydroxy vitamin D, and disease activity in knee OA.Methods: In a case-control study, 60 patients with knee OA were selected based on the criteria of the American College of Rheumatol- ogy referred to the Rheumatology Department of Tabriz University of Medical Sciences, Tabriz, Iran, from October 2017 to February 2018. Also, 28 healthy subjects matched regarding age and sex were selected. The patients were examined, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Index) was assessed. Serum levels of COMP and 25-hydroxy vitamin D were assessed by ELISA method.Results: The mean ± SD age of the patients and controls was 57.60 ± 10.63 and 56.46 ± 5.58 years, respectively. Serum COMP was significantly higher in OA patients (40.82 ± 10.04 pg/mL) than in healthy controls (27.01 ± 9.64 pg/mL) (P < 0.001). There were no statistically significant differences in serum 25-hydroxy vitamin D between the patients and control subjects (P = 0.361). Significant correlations were found between serum COMP concentration with WOMAC score (r = -0.290, P = 0.025) as well as the grade of OA (r = 0.362, P = 0.004). No statistically significant correlations were found between serum 25-hydroxy vitamin D level with WOMAC score (r = 0.102, P = 0.438) and the grade of OA (r = - 0.063, P = 0.630) as well as between serum COMP and 25-hydroxy vitamin D levels (P > 0.05).Conclusions: Based on the results of our study, Serum COMP levels correlated with disease characteristics in patients with os- teoarthritis. Although further studies are needed to confirm our results, COMP may be used as a possible novel marker to measure osteoarthritis development and progression.
Hassan Argani; Amirhesam Alirezaei; Amir Ghorbanihaghjo; Tabasom Azizi; Massomeh Asgharpour; Mahmood Bakhtiyari
Volume 20, Issue 3 , 2018, Pages 1-7
Abstract
Background: Increasing evidence implies that Adipocytokines may result in cardiovascular disease (CVD) events and metabolic changes in the general population and also increase graft failure rate in the renal transplant recipient.Objectives: To compare the serum levels of Adipocytokines and lipid profiles ...
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Background: Increasing evidence implies that Adipocytokines may result in cardiovascular disease (CVD) events and metabolic changes in the general population and also increase graft failure rate in the renal transplant recipient.Objectives: To compare the serum levels of Adipocytokines and lipid profiles in renal transplant recipients with healthy individuals. Methods: In a case-control study undertaken from the beginning of 2015 to December 2016; 30 renal transplant recipients, with sta- ble conditions, whose renal transplant at least survived well over six months, were randomly selected to be the case group. Besides, 30 healthy individuals who referred to the transplantation clinic as the patients’ attendants were considered as the control group. The serum levels of IL-1, IL-6, TNF-α, Adiponectin, Visfatin, Leptin, and the Lipid profiles were measured after 12 hours of fasting and were compared between the two groups.Results: The serum levels of Adipocytokines including IL-1, IL-6, TNF-α, Visfatin, and Leptin were significantly higher in renal trans- plant recipients than in healthy individuals (P <0.001) and the serum level of adiponectin (P < 0.004) was significantly lower in the renal transplant recipients. Linear regression results indicated that in the renal transplant group, only the Visfatin had a sig- nificant negative correlation with age (Unstandardized Coefficient = -0.104, P = 0.002). There were significant positive correlations between Leptin with cholesterol (P = 0.005), triglyceride (P = 0.008), and LDL (P = 0.014) in the healthy individuals, however, these re- lationships were not found in the renal transplant recipients and only a significant negative correlation was found between Tumor necrosis factor alpha (TNF-α) and cholesterol levels (P = 0.01). Conclusions: The findings of the present study demonstrated that renal transplant recipients suffer from inflammation and ac- companying changes in levels of Adipocytokines in comparison with healthy controls
